IF invites you to the No.1 IF Colloquium (Online Seminar Series)
Title: ” Fighting Cancer with Computational Nanophysics “ Speaker: Assoc. Prof. Dr. Theerapong Puangmali(Materials Science and Nanotechnology Program, Department of Physics, Faculty of Science, Khon Kaen University)
Abstract: DNA methylation is an epigenetic modification involving the transfer of a methyl group to cytosine residues of the DNA molecule, forming 5-methylcytosine (5mC). DNA methylation patterns are related to embryonic development, aging, and age-associated diseases such as cancer. Overall genomic methylation levels and the total population of the 5mC residues can reflect epigenetic defects, which can lead to various diseases. Distinct DNA methylation levels can be found between normal and cancer genomes. Nanomaterials, such as graphene oxide, gold nanoparticles, carbon quantum dot, offer great potential as sensing elements for methylated DNA (mDNA) detection due to their distinct properties. In this talk, molecular dynamics (MD) simulation and density functional theory (DFT)calculation have been employed for investigating their signature interactions between nanomaterials and cancer DNA at macroscopic and microscopic levels. Our findings provide a new route for an efficient detection method of DNA methylation, which can further be used to develop a universal cancer test. Venue: IF Channel https://youtu.be/sA6McK88538