IF invites you to the No.6 IF Colloquium (Online Seminar Series)
Title: ” Protein Engineering from Physicists’ Point of View “ Speaker: Asst. Prof. Thana Sutthibutpong, Ph.D.(Lecturer in Physics, Theoretical and Computational Physics Group, Department of Physics, Faculty of Science, King Mongkut’s University of Technology Thonburi (KMUTT), Thailand. )
Thana Sutthibutpong received his PhD degree from the University of Leeds in 2015. Currently he is a Asst Prof in the Department of Physics, KMUTT. His research interests focus on applying molecular simulation techniques to explain molecular mechanisms underlying biomolecules and materials.
Abstract:This talk presents basic principles of protein engineering aided by molecular simulation techniques. We start with a brief introduction to proteins for their origins and their functions as molecular motors and enzymes in terms of their structural components. We then discuss about how protein structures hierarchy are defined into primary, secondary, and tertiary structures so that certain patterns of protein folding can be understood in terms of physical interactions. This understanding leads to a new research field, protein engineering, in which evolution of proteins at the molecular level is mimicked and accelerated by altering a few amino acids, which affecting both local physical properties and the global interaction network. After that, we discussed about some basic principles and theoretical backgrounds of molecular simulations and their applications in protein engineering in collaborations with experimental labs. Finally, we discussed on the current advances and future trends of the protein structure research involving new techniques, such as, machine learning and network theory.
Keywords: Molecular Simulations, Protein Engineering, Fibrilization, Network Topology. IF Channel : https://youtu.be/XakX4sdwQQY